News
CLAIRIgene selected to present at AAIC. To view the poster click below
CLAIRIgene featured in MedicalNewsToday
CLAIRIgene featured by STAT News
CLAIRIgene’s Alzheimer’s program received its first STTR award from the National Institute on Aging of the National Institutes of Health for the project entitled, “APOE-targeted therapy for precision medicine in late onset Alzheimer’s disease: A novel epigenome editing approach for downregulation of APOEe4 expression”
Dr. Kantor discussed CLAIRIgene’s APOE-targeted epigenome therapy for Alzheimer’s in an interview for VJDementia as part of the journal series for AAIC 2022.
Click at the link Developing APOE targeted epigenome therapy for the treatment of Alzheimers Disease to listen to the interview.
Dr. Chiba-Falek participated as a panelist in the Alzheimer’s Association Business Consortium (AABC) Panel at the AAIC 2022 for a discussion on Therapeutic targets & strategies in Alzheimer’s disease
CLAIRIgene welcome Dr. Hamm to the leadership team to lead the business development of the company.
Dr. Chiba-Falek joined Susan Ryan, a senior director at The Green House Project, to the episode “Editing the genetics of Alzheimer’s” in the podcast series “Elevate Eldercare” to discuss her groundbreaking work, and what it could eventually mean for families and caregivers.
Click at the link, to listen to the podcast broadcasted on February 9, 2022 Green House Podcast: Elevate Eldercare – Green House Project (thegreenhouseproject.org)
CLAIRIgene was awarded a SRA from Seelos Therapeutics for a research project entitled: “Neuronal-type specific gene therapy for dementia with Lewy Body”
CLAIRIgene was awarded a SRA from Seelos Therapeutics for a research project entitled: “Modeling of neurodegenerative diseases via an all-in-one bimodal lentiviral vector”
Publications
Relevant Work:
Kantor B and Chiba-Falek O. Lentiviral vectors as the delivery vehicles for transduction into iPSCs: shortcomings and benefits 2021 Methods in iPSC Technology Volume 9 in Advances in Stem Cell Biology2021, Pages 79-100
Dong W, Kantor B. Viruses. 2021 Jul 1;13(7):1288. doi: 10.3390/v13071288. PMID: 34372494 Free PMC article. Review.
Yang A, Kantor B, Chiba-Falek O. Int J Mol Sci. 2021 Jan 27;22(3):1244. doi: 10.3390/ijms22031244. PMID: 33513969 Free PMC article. Review.
4. An Improved Protocol for the Production of Lentiviral Vectors.
Brown LY, Dong W, Kantor B. STAR Protoc. 2020 Oct 27;1(3):100152. doi: 10.1016/j.xpro.2020.100152. eCollection 2020 Dec 18. PMID: 33377046 Free PMC article.
MacDougall G, Brown LY, Kantor B, Chiba-Falek O. Mol Ther. 2021 Mar 3;29(3):949-972. doi: 10.1016/j.ymthe.2021.01.001. Epub 2021 Jan 9. PMID: 33429080 Review.
Rittiner JE, Moncalvo M, Chiba-Falek O, Kantor B. Front Mol Neurosci. 2020 Aug 12;13:148. doi: 10.3389/fnmol.2020.00148. eCollection 2020. PMID: 32903507 Free PMC article.
Gamache J, Yun Y, Chiba-Falek O. Dis Model Mech. 2020 Aug 27;13(8):dmm045211. doi: 10.1242/dmm.045211. PMID: 32859588 Free PMC article. Review.
Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145):10.3791/59241. doi: 10.3791/59241. PMID: 30985756 Free PMC article.
Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O. Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29. PMID: 30266652 Free PMC article.
Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130):56915. doi: 10.3791/56915. PMID: 29286484 Free PMC article.
Ortinski PI, O’Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PMID: 28497073 Free PMC article.
12. The Role of Upregulated APOE in Alzheimer’s Disease Etiology.
Gottschalk WK, Mihovilovic M, Roses AD, Chiba-Falek O. J Alzheimers Dis Parkinsonism. 2016 Mar;6(1):209. doi: 10.4172/2161-0460.1000209. Epub 2016 Feb 9. PMID: 27104063 Free PMC article. No abstract available