News

Publications

Relevant Work:

1. Lentiviral vectors as the delivery vehicles for transduction into iPSCs: shortcomings and benefits – ScienceDirect

Kantor B and Chiba-Falek O. Lentiviral vectors as the delivery vehicles for transduction into iPSCs: shortcomings and benefits 2021 Methods in iPSC Technology Volume 9 in Advances in Stem Cell Biology2021, Pages 79-100

2. Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives.

Dong W, Kantor B. Viruses. 2021 Jul 1;13(7):1288. doi: 10.3390/v13071288. PMID: 34372494 Free PMC article. Review.

3. APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer’s.

Yang A, Kantor B, Chiba-Falek O. Int J Mol Sci. 2021 Jan 27;22(3):1244. doi: 10.3390/ijms22031244. PMID: 33513969 Free PMC article. Review.

4. An Improved Protocol for the Production of Lentiviral Vectors.

Brown LY, Dong W, Kantor B. STAR Protoc. 2020 Oct 27;1(3):100152. doi: 10.1016/j.xpro.2020.100152. eCollection 2020 Dec 18. PMID: 33377046 Free PMC article.

5. The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.

MacDougall G, Brown LY, Kantor B, Chiba-Falek O. Mol Ther. 2021 Mar 3;29(3):949-972. doi: 10.1016/j.ymthe.2021.01.001. Epub 2021 Jan 9. PMID: 33429080 Review.

6. Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases.

Rittiner JE, Moncalvo M, Chiba-Falek O, Kantor B. Front Mol Neurosci. 2020 Aug 12;13:148. doi: 10.3389/fnmol.2020.00148. eCollection 2020. PMID: 32903507 Free PMC article.

7. Sex-dependent effect of APOE on Alzheimer’s disease and other age-related neurodegenerative disorders.

Gamache J, Yun Y, Chiba-Falek O. Dis Model Mech. 2020 Aug 27;13(8):dmm045211. doi: 10.1242/dmm.045211. PMID: 32859588 Free PMC article. Review.

8. Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.

Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145):10.3791/59241. doi: 10.3791/59241. PMID: 30985756 Free PMC article.

9. Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.

Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O. Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29. PMID: 30266652 Free PMC article.

10. A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells.

Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130):56915. doi: 10.3791/56915. PMID: 29286484 Free PMC article.

11. Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing.

Ortinski PI, O’Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PMID: 28497073 Free PMC article.

12. The Role of Upregulated APOE in Alzheimer’s Disease Etiology.

Gottschalk WK, Mihovilovic M, Roses AD, Chiba-Falek O. J Alzheimers Dis Parkinsonism. 2016 Mar;6(1):209. doi: 10.4172/2161-0460.1000209. Epub 2016 Feb 9. PMID: 27104063 Free PMC article. No abstract available